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Participating research groups

Principal Investigator

Research Interest


Spokesperson of the GRK 1873

Prof. Dr. Alexander Pfeifer
Institute of Pharmacology & Toxicology,
Biomedical Center,
Faculty of Medicine

  • Signaling: NO/cGMP pathway - GPCR signaling
  • Metabolism and adipogenesis
  • Drug targeting - Nanomedicine
  • Viral vector platform: Focus on lentiviral vectors, lentiviral transgenesis (production of transgenic animals using lentiviral gene transfer)
  • Animal models: Lentiviral transgenesis and knockout mice
  • RNA interference: siRNA-based therapeutic approaches, the role of microRNAs in neurodegeneration and stem cell differentiation
  • Stem cells; focus on mesenchymal stem cell differentiation
Prof. Dr. Jens Brüning
Max Planck Institute for Metabolism Research, Cologne


  • CNS-dependent control of metabolism
  • GPCR signaling in control of feeding and peripheral metabolism
  • Immunometabolism
  • Transgenic mouse models
  • Crispr/Cas-mediated gene editing in vivo
  • Molecular systems neuroscience (optogenetics, functional neurocircuitry analyses)
Prof. Dr. Bernd Fleischmann
Institute of Physiology I,
Life & Brain Center,
Faculty of Medicine

  • Stem cell biology
  • Cardiovascular physiology and pathophysiology
  • Developmental physiology, cell physiology
  • Signal transduction
  • Cell culture, cell biology, ES and iPS cell technology
  • Cell physiology (patch clamp, confocal imaging, electrode arrays, wide-field imaging)
  • Integrative cardiovascular physiology (cardiac disease models)
  • Generation of transgenic animals, tetraploid complementation assays
Vice-spokesperson of the GRK 1873
(since 2016)

Prof. Dr. Evi Kostenis
Institute of Pharmaceutical Biology,
Faculty of Mathematics & Natural Sciences

  • Liganded and orphan G protein-coupled receptors
  • G proteins
  • Signal transduction
  • Classical second messenger assays covering all G protein pathways
  • MAP kinase and internalization studies
  • BRET-based methods to monitor protein-protein interactions (ß-arrestin recruitment)
  • Label-free biosensor platforms based on dynamic mass redistribution and impedance
  • Molecular biology, mammalian cell culture, genetic engineering, Western-, Northern-, Southernblotting, quantitative PCR, fluorescence microscopy
Prof. Dr. Christa E. Müller
Pharmaceutical Institute,
Pharmaceutical/Medicinal Chemistry,
Faculty of Mathematics & Natural Sciences

  • Medical chemistry, chemical biology and molecular pharmacology of purinergic receptors (adenosine, P2Y, P2X, adenine receptors)
  • G protein-coupled receptors/orphan GPCRs
  • Ectonucleotidase inhibitors
  • Development of screening assays
  • Synthesis of drug molecules (small molecules)
  • Combinatorial synthesis, microwave-assisted synthesis
  • Molecular biological techniques (expression in mammalian cells, insect cells and yeast), mutagenesis studies)
  • Development of radioligands (including PET-ligands), fluorescent ligands and ESR probes
  • Isotope laboratories
  • GM-S2-laboratories
  • NMR (600 MHz and 500 MHz), LCMS, CE
  • Professional compound library
  • Automatic screening unit
Prof. Dr. Benjamin Odermatt
Institute of Anatomy,
Faculty of Medicine

  • Regulation of CNS-myelination
  • Myelinating diseases and CNS-myelin regeneration
  • Embryonic-tissue development
  • Development of in vivo multi-photon light sheet microscopy
  • Zebrafish facility: Focus on CNS and myelin transgenic-fish lines (reporter and mutant)
  • In vivo deep tissue fluorescent imaging
  • Genetically encoded fluorescent reporter-proteins
  • Transient genetically knock-down and over-expression studies
  • Developmental analysis
Prof. Dr. Philipp Sasse
Institute of Physiology I,
Life & Brain Center,
Faculty of Medicine

  • Developmental physiology of the sinus node
  • Disease-specific induced pluripotent stem cells (iPS cells)
  • Optogenetics in cardiovascular physiology
  • Magnetic nanoparticle-based gene transfer
  • Biological pacemakers

  • Mouse and human iPS cell culture, differentiation of cardiomyocytes
  • Manual patch clamp, automatic planar path clamp, confocal imaging, micro-electrode arrays, in vivo imaging
  • Optogenetical stimulation of cells and organs in vivo and in vitro
Prof. Dr. Andreas Schlitzer

Quantitative Systems Biology, Life & Medical Sciences Institute (LIMES), Faculty of Mathematics and Natural Sciences


  • Development and function of monocytes and dendritic cells
  • Bone marrow niches of myeloid cell development
  • Regulation of myeloid cell development during inflammation
  • Impact of dietary mediators on myeloid cell development
  • In vivo & in vitro myeloid development assays
  • Functional analysis of dendritic cells and monocytes
  • Murine models of myeloid cell deficiencies
  • Single cell transcriptomics
  • Human myeloid cell culture

Prof. Dr. Elvira Mass, Developmental Biology of the Immune System,
Life & Medical Sciences Institute (LIMES), Faculty of Mathematics and Natural Sciences


  • Developmental Immunology
  • Kupffer cell signalling in hepatic metabolism
  • non-immunological functions of macrophages
  • Murine models targeting distinct developmental arms of hematopoiesis
  • RNA-seq
  • high-dimensional flow cytometry