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Welcome to the Research Training Group 1873!

"Pharmacology of 7TM-receptors and downstream signaling pathways"

 

  

Congratulations!

 

Our PhD students successfully published as first authors or co-first authors:

 

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt N-K, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.
The orphan receptor GPR17 is unresponsive to uracil-nucleotides and cysteinyl-leukotrienes.
Mol Pharmacol. 2017,

De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, Tränkle C, De Amici M, Kenakin T, Holzgrabe U, Dallanoce C,
Kostenis E, Mohr K, Schrage R.
A new molecular mechanism to engineer protean agonism at a G protein-coupled receptor.
Mol Pharmacol. 2017, Feb 6; DOI: https://doi.org/10.1124/mol.116.107276

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.
Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.
J Clin Invest. 2016 Sep 12. pii: 88950. doi: 10.1172/JCI88950.

Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A.
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
Nat Commun. 2016 Apr 27;7:11420.doi:10.1038/nccomms11420.

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.
The Gq signalling pathway inhibits brown and beige adipose tissue.
Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895.

Engelhardt B, Fröhlich H, Kschischo M.
Learning (from) the errors of a systems biology model.
Sci Rep. 2016 Feb 11;6:20772. doi: 10.1038/srep20772.

Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J.
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
J Biol Chem. 2016 Jan 8;291(2):705-18. doi: 10.1074/jbc.M115.683953.

 

 

 

 

 

 


 

 

 


 

 

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