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Welcome to the Research Training Group 1873!

"Pharmacology of 7TM-receptors and downstream signaling pathways"





Our PhD students successfully published as first authors or co-first authors:


Kannabiran SA, Gosejacob D, Niemann B, Nikolaev VO, Pfeifer A.
Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β1 and β3-adrenoceptor signalling.
Mol Metab. 2020:100986. doi: 10.1016/j.molmet.2020.100986.

Klepac K, Yang J, Hildebrand S, Pfeifer A.
RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation.
Mol Metab. 2019 Dec;30:173-183. doi: 10.1016/j.molmet.2019.09.015.

Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E.
Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.
ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254. 


Bruegmann T, Beiert T, Vogt CC, Schrickel JW, Sasse P.
Optogenetic termination of atrial fibrillation in mice.
Cardiovasc Res. 2018 Apr 1;114(5):713-723. doi: 10.1093/cvr/cvx250.

Lapp H, Bruegmann T, Malan D, Friedrichs S, Heidsieck A, Kilgus C, Sasse P.
Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.
Sci Rep. 2017, 7:9629 doi:10.1038/s41598-017-09760-7

Engelhardt B, Holze J, Elliott C, Baillie GS, Kschischo M, Fröhlich H.
Modeling and mathematical analysis of the M2-receptor dependent joint signaling and
secondary messenger network in CHO cells.
Math Med Biol. 2017, May 15. doi: 10.1093/imammb/dqx003.
Engelhardt B, Kschischo M, Fröhlich H.
A Bayesian approach to estimating hidden variables as well as missing and wrong molecular interactions in ordinary differential equation-based mathematical models.
J R Soc Interface. 2017 Jun;14(131). pii: 20170332. doi: 10.1098/rsif.2017.0332.

Simon K, Merten N, Schröder R, Hennen S, Preis P, Schmitt N-K, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E.
The orphan receptor GPR17 is unresponsive to uracil-nucleotides and cysteinyl-leukotrienes.
Mol Pharmacol. 2017,

De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, Tränkle C, De Amici M, Kenakin T, Holzgrabe U, Dallanoce C,
Kostenis E, Mohr K, Schrage R.
A new molecular mechanism to engineer protean agonism at a G protein-coupled receptor.
Mol Pharmacol. 2017, Feb 6; DOI:

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.
Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.
J Clin Invest. 2016 Sep 12. pii: 88950. doi: 10.1172/JCI88950.

Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A.
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
Nat Commun. 2016 Apr 27;7:11420.doi:10.1038/nccomms11420.

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.
The Gq signalling pathway inhibits brown and beige adipose tissue.
Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895.

Engelhardt B, Fröhlich H, Kschischo M.
Learning (from) the errors of a systems biology model.
Sci Rep. 2016 Feb 11;6:20772. doi: 10.1038/srep20772.

Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J.
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
J Biol Chem. 2016 Jan 8;291(2):705-18. doi: 10.1074/jbc.M115.683953.